Objective. To disclose the biological role of nitric oxide, its metabolism and the mechanism of action in tissues during physical exercise, as well as the possibility of correction of tissue metabolism through the NO system in athletes.
Methods. Analysis and generalization of scientific literature data.
Results. It was found that, in skeletal muscle and other body tissues, activation of nitric oxide metabolic system occurs. Then, this system becomes engaged in cellular mechanisms inducing adaptation processes inasmuch as it is involved in regulation of energy metabolism in tissues, biosynthesis of cytoskeleton and contractile proteins, maintenance of an optimal balance of prooxidant and antioxidant processes. Under intense training loads, and development of pathological processes in myocardial and skeletal muscles, excessive accumulation of nitric oxide has enhanced oxidative stress and this contributes to the development of fatigue or diseases of cardio-vascular and other systems of the body.
Conclusion. The further study of nitric oxide role in the adaptation of athlete’s organism in various sports would be very interesting.